Stratified cluster sampling, retrospective analysis of clinical data of 88 patients with early preeclampsia admitted to our hospital from May 2017 to May 2019,Include 42 patients with plasma PLGF level >12pg/mL that day into the high-level group,Age 22-36 years old, average age (29.523.45) years; 1-3 parities, average parity (1.560.21) times; 42 patients with plasma PLGF level 12pg/mL that day were included in the high-level group, age 22-36 years old, average age (29.623.49) years; parity 1-3 times, average parity (1.620.25) times. There was no significant difference in parity and age between the two groups of patients (P>0.05), and they were comparable.

On the day of delivery, 5 mL of fasting venous blood was drawn from the patient for examination, and the blood sample was centrifuged and plasma separated, and the PLGF content was detected in strict accordance with the operating procedure.

Evaluation indicators: (1) Perinatal outcome of the two groups of patients: observe and record the gestational age, oligohydramnios, fecal staining of amniotic fluid, and small-for-gestational age infants of the two components, and compare and analyze them. (2) Newborn condition: Radial artery blood is drawn within 1h after birth, and the following tests are done:Apgar, NICU hospitalization time, lactic acid, alkali excess, blood glucose, and blood calcium within 1 min were recorded and compared and analyzed.

● Perinatal outcome: the gestational week of the high-level group was (35.681.88) weeks, which was longer than that of the low-level group (33.722.25), and the difference was statistically significant (t=4.411, p=0.000); compared with the high-level group In the low-level group, the incidence of oligohydramnios, small-for-gestational age infants and amniotic fluid fecal staining were higher, and the difference was statistically significant (p<0.05).

 

 

 

 

● Newborn condition: Compared with the high-level group, the low-level group has a lighter birth weight, a lower Apgar score within 1 minute, a longer hospital stay in the NICU, a higher lactic acid level, a lower alkaline excess, and a lower blood calcium level. There are differences Statistically significant (p<0.05); there was no statistically significant difference in blood glucose levels between the two groups of newborns (p>0.05)

The mechanism of early-onset preeclampsia is that the trophoblast cells in the first trimester have insufficient erosion of the spiral artery of the uterus, which leads to shallow placental implantation and insufficient blood perfusion, which eventually leads to damage to the vascular endothelium and ischemia of placental trophoblast cells. Symptoms of pregnancy-induced hypertension.

PLGF is of great significance to placenta formation and fetal development. Therefore, in-depth research on the correlation between PLGF and pregnancy outcome is particularly important to improve clinical pregnancy outcomes.The results of this study indicate that early detection of placental growth factor levels in patients with early-onset preeclampsia can predict the perinatal outcome. For patients with low levels of placental growth factor, there is a greater possibility of adverse outcomes. Clinically targeted at such Patients should strengthen intervention.