School of Diagnostics｜The clinical value of N-terminal pro-brain natriuretic peptide

Categories:College of Diagnostics
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Time of issue:2020-07-20
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(Summary description)First understand the difference between "brain natriuretic peptide" and "amino-terminal pro-brain natriuretic peptide"

N-terminal pro-brain natriuretic peptide (NT-proBNP) and BNP have the same biological source, and both are used for clinical testing. After ventricular myocytes are stimulated by pressure, they produce a B-type natriuretic peptide precursor (pre-proBNP) containing 134 amino acids, and then the signal peptide is removed to form a BNP precursor containing 108 amino acids (proBNP).

School of Diagnostics｜The clinical value of N-terminal pro-brain natriuretic peptide

(Summary description)First understand the difference between "brain natriuretic peptide" and "amino-terminal pro-brain natriuretic peptide"

N-terminal pro-brain natriuretic peptide (NT-proBNP) and BNP have the same biological source, and both are used for clinical testing. After ventricular myocytes are stimulated by pressure, they produce a B-type natriuretic peptide precursor (pre-proBNP) containing 134 amino acids, and then the signal peptide is removed to form a BNP precursor containing 108 amino acids (proBNP).

Categories:College of Diagnostics
Author:
Origin:
Time of issue:2020-07-20
Views:0

First understand the difference between "brain natriuretic peptide" and "amino-terminal pro-brain natriuretic peptide"

N-terminal pro-brain natriuretic peptide (NT-proBNP) and BNP have the same biological source, and both are used for clinical testing. After ventricular myocytes are stimulated by pressure, they produce a B-type natriuretic peptide precursor (pre-proBNP) containing 134 amino acids, and then the signal peptide is removed to form a BNP precursor containing 108 amino acids (proBNP).

Under the action of endonuclease, proBNP is cleaved into NT-proBNP with 76 amino acids and no biological activity and BNP with 32 amino acids and biological activity. The two are released into the blood at a ratio of 1:1. Although the clearance of the two in the body is different, under most physiological and pathological conditions, the levels of the two in the blood show a certain correlation. Therefore, both can be used for the diagnosis and prognosis assessment of heart failure, and the clinical application results are the same.

Brain natriuretic peptide (BNP) is also called B-type natriuretic peptide and B-type natriuretic peptide, but the most formal name is B-type natriuretic peptide. It is named for its powerful natriuretic, diuretic, vasodilator and blood pressure effects that were isolated from pig brain for the first time. NT-proBNP and BNP are currently the most important cardiac function biomarkers.

Note: The longer the half-life, the higher the concentration in the body, which is easier to detect; in addition, it can reflect the changes in heart function over a longer period of time.

The better the stability, the better the detection. Degradation is too fast, and the test results cannot faithfully reflect changes in cardiac function.

Secondly, understand the risk stratification and prognosis interpretation

BNP and (or) NT-proBNP can predict the long-term risk of death in patients with heart failure, have high specificity and sensitivity for the diagnosis of heart failure, and are positively correlated with the severity of heart failure.

● （1）NT-proBNP>5000pg/mL indicates that patients with heart failure have a higher short-term mortality risk; >1000pg/mL may indicate a higher risk of long-term death in patients with heart failure.

● （2）Dynamic monitoring of BNP or NT-proBNP can be used as an auxiliary means to evaluate the efficacy of heart failure, and the reduction of BNP and (or) NT-proBNP level ≥30% can be used as a criterion for effective treatment.

● （3）During the hospitalization of patients with heart failure, BNP and (or) NT-proBNP levels significantly increased or remained high without falling, or decreased by less than 30%, all of which indicated an increased risk of rehospitalization and death.

● （4）BNP or NT-proBNP is a powerful predictor of the development of heart failure or the existence of impaired left ventricular systolic function. BNP can also assist in judging the prognosis of patients with chest pain. Elevated BNP or NT-proBNP is associated with serious adverse events and death in patients with pulmonary embolism. BNP is more sensitive and specific than NT-proBNP in detecting right ventricular function.

Finally, learn about the clinical application of N-terminal pro-brain natriuretic peptide (NT-proBNP)

01

Auxiliary clinical differential diagnosis and prognosis of acute heart failure

02

Guide the risk stratification and treatment evaluation of chronic heart failure

03

Differential diagnosis of acute dyspnea

04

Prognosis of coronary heart disease

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Ningbo Aocheng Biotechnology Co., Ltd. is a high-tech biological enterprise focusing on the early detection, diagnosis, prevention and monitoring of diseases. By providing reliable, fast and convenient in vitro diagnostic products, it can provide accurate test results for diagnosis and treatment.

At present, the company's biomedical team continues to conduct in-depth exploration and prospective research in the field of high-risk diseases for pregnant women such as hypertension.We will be committed to providing leading clinical diagnosis solutions for women and children's health. Promote the standardized management of perinatal preeclampsia in my country, and contribute to the predictive management of preeclampsia in the world.