Preeclampsia is a common serious complication in pregnant women. It refers to abnormal symptoms such as hypertension and proteinuria after 20 weeks of pregnancy, or accompanied by impaired maternal organ function and fetal complications. The incidence of preeclampsia in my country is 2%~5%, causing about 15% of fetuses to be born prematurely and 42% of maternal deaths, seriously affecting the health of mothers and babies. Therefore, screening for early diagnostic markers of preeclampsia, early intervention and monitoring of high-risk preeclampsia pregnant women, prevention and treatment of preeclampsia, and improvement of pregnancy outcomes are of great significance.

Nowadays, with the advancement of medical technology and continuous in-depth exploration and research on pre-eclampsia, doctors can identify and discover pre-eclampsia earlier. Studies have shown that placental growth factor (PLGF) is the most capable of identifying pre-eclampsia. Biochemical markers can effectively predict preeclampsia in the early pregnancy and can identify high-risk groups of preeclampsia, so that necessary measures can be initiated as soon as possible to improve placenta formation and prevent or reduce the incidence of preeclampsia. In addition, identifying "at risk" groups can help tailor prenatal monitoring to predict and identify the onset of clinical syndromes and deal with them in a timely manner.

In the 2019 FIGO guidelines, it is recommended that all pregnant women should be screened for early preeclampsia through the combination of early pregnancy testing and maternal risk factors and biomarkers in the first trimester. The best combination of testing includes maternal risk factors, mean arterial pressure (MAP) ), serum placental growth factor (PlGF) and uterine arterial pulsatility index (UTPI). The selected high-risk population needs to take early intervention measures. In addition, the latest guidelines for the diagnosis and treatment of hypertension in pregnancy (2020) also mention the latest The study put forward the best prediction method is PLGF combined with maternal factors, MAP, uterine artery pulsatility index (UTPI), higher accuracy.